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Index > Protein center > GFER(Gene name) > Human
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  • GFER (Gene name),
  • FAD-linked sulfhydryl oxidase ALR (Protein name ),  ALR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GFER(ALR;HERV1;HPO);
    Protein name:
    FAD-linked sulfhydryl oxidase ALR;
    Alternative:
    Hepatopoietin;Augmenter of liver regeneration(hERV1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. May form heterodimers of isoform 1 and isoform 2.
    Function:
    Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
    Subcellular Location:
    Isoform 2 Cytoplasm Secreted
    Protein Attributes:
    Sequence length:
    205
    Sequence:
    50:
    MAAPGERGRF | HGGNLFFLPG | GARSEMMDDL | ATDARGRGAG | RRDAAASAST | 
    100:
    PAQAPTSDSP | VAEDASRRRP | CRACVDFKTW | MRTQQKRDTK | FREDCPPDRE | 
    150:
    ELGRHSWAVL | HTLAAYYPDL | PTPEQQQDMA | QFIHLFSKFY | PCEECAEDLR | 
    200:
    KRLCRNHPDT | RTRACFTQWL | CHLHNEVNRK | LGKPDFDCSK | VDERWRDGWK | 
    205:
    DGSCD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    KEGG:
    SMR:
    UniGene:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    E13738h
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    96T
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    ELISA Kit for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    E13738m
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    Packing:
    96T
    ELISA Kit for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    E13738r
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    Packing:
    96T
    CLIA Kit for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    U13738r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    U13738h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    U13738m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    P13738Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    P13738Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human FAD-linked sulfhydryl oxidase ALR
    Cat.:
    P13738Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human FAD-linked sulfhydryl oxidase ALR
    Monoclonal Antibody for Human FAD-linked sulfhydryl oxidase ALR
    Monoclonal Antibody for Human FAD-linked sulfhydryl oxidase ALR
    Protein for Human FAD-linked sulfhydryl oxidase ALR
    Protein for Human FAD-linked sulfhydryl oxidase ALR
    Protein for Human FAD-linked sulfhydryl oxidase ALR

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    Linearity
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    References
    1. 1.
      "Genomic structure, chromosomal localization, and characterization of a functional promoter for human hepatopoietin (HPO) gene."
      Liu M.-M. , He F.-C. , Wei H.-D. , Zhou W.-Q.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "HERV different transcription sequence."
      Li Y. , Xing G.-C. , He F.-C. , Wei H.-D. , Zhang C.-G. , Zhu L. , Yu Y.-T.
      Submitted (1999-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Liver.
    3. 3.
      "Isolation of human HPO cDNA from human liver tissue."
      Jun L. , Wangxiang X. , Xiaoming Y.
      Submitted (2000-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fetal liver.
    4. 4.
      "Human augmenter of liver regeneration/hepatopoietin gene open reading frame sequence."
      Dai W.-J. , Jiang H.-C.
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-205
      tissue: Placenta.
      tissue: Skin.
    7. 7.
      "Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis."
      Cheng J. , Zhong Y.
      Zhonghua Gan Zang Bing Za Zhi8:12-14(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-205
    8. 8.
      "A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast."
      Lisowsky T. , Weinstat-Saslow D.L. , Barton N. , Reeders S.T. , Schneider M.C.
      Genomics29:690-697(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-205
      tissue: Renal cyst lining cell.
    9. 9.
      "Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription."
      Li Y. , Wei K. , Lu C. , Li Y. , Li M. , Xing G. , Wei H. , Wang Q. , Chen J. , Wu C. , Chen H. , Yang S. , He F.
      Eur. J. Biochem.269:3888-3893(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;SUBUNIT
    10. 10.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space."
      Daithankar V.N. , Farrell S.R. , Thorpe C.
      Biochemistry48:4828-4837(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40."
      Sztolsztener M.E. , Brewinska A. , Guiard B. , Chacinska A.
      Traffic14:309-320(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    15. 15.
      "Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy."
      Daithankar V.N. , Schaefer S.A. , Dong M. , Bahnson B.J. , Thorpe C.
      Biochemistry49:6737-6745(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 81-205;CATALYTIC ACTIVITY;FUNCTION;SUBUNIT;DISULFIDE BONDS;FAD-BINDING SITES;CHARACTERIZATION OF VARIANT MPMCHD HIS-194
    16. 16.
      "Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR."
      Banci L. , Bertini I. , Calderone V. , Cefaro C. , Ciofi-Baffoni S. , Gallo A. , Kallergi E. , Lionaki E. , Pozidis C. , Tokatlidis K.
      Proc. Natl. Acad. Sci. U.S.A.108:4811-4816(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 81-205 IN COMPLEX WITH FAD;FUNCTION;COFACTOR;SUBUNIT;DISULFIDE BONDS;INTERACTION WITH CHCHD4
    17. 17.
      "An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR."
      Banci L. , Bertini I. , Calderone V. , Cefaro C. , Ciofi-Baffoni S. , Gallo A. , Tokatlidis K.
      J. Am. Chem. Soc.134:1442-1445(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 91-205;FUNCTION;CATALYTIC ACTIVITY;DISULFIDE BONDS;SUBUNIT
    18. 18.
      "The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency."
      Di Fonzo A. , Ronchi D. , Lodi T. , Fassone E. , Tigano M. , Lamperti C. , Corti S. , Bordoni A. , Fortunato F. , Nizzardo M. , Napoli L. , Donadoni C. , Salani S. , Saladino F. , Moggio M. , Bresolin N. , Ferrero I. , Comi G.P.
      Am. J. Hum. Genet.84:594-604(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPMCHD HIS-194;CHARACTERIZATION OF VARIANT MPMCHD HIS-194;TISSUE SPECIFICITY
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